
Ready for a world withOUT antibiotics?
A bedrock of modern medicine but in the near future, we’re going to have to learn to live without them
Sarah Boseley
In just a couple of generations, what once appeared to be miracle medicines have been beaten into ineffectiveness by the bacteria they were designed to knock out. Once, scientists hailed the end of infectious diseases. Now, the postantibiotic apocalypse is within sight.Lancet Infectious Diseases this week posed the question over a paper revealing the rapid spread of multi-drug-resistant bacteria.
Hyperbole? Unfortunately not.
The highly serious journal
“Is this the end of antibiotics?” it asked.
Doctors and scientists have not been complacent, but the paper by Professor Tim Walsh and colleagues takes the anxiety to a new level. Last September, Walsh published details of a gene he had discovered, called NDM1 (New Delhi Metallobeta-lactamase 1), which passes easily between types of bacteria and makes them resistant to almost all the powerful, last-line antibiotics called carbapenems.
This week’s paper revealed that NDM1 is widespread in India and has arrived as a result of global travel and medical tourism for, among other things, transplants, pregnancy and cosmetic surgery.
(The paper has triggered a storm of protest from India’s medical industry. Reports from India cited Indian doctors saying that the warnings about this drugresistant superbug were alarmist.)
Walsh disagrees: “This is potentially the end.
There are no antibiotics in the pipeline that have activity against NDM 1-producing enterobacteriaceae. We have a bleak window of maybe 10 years, where we are going to have to use the antibiotics we have very wisely, but also grapple with the reality that we have nothing to treat these infections with.”
And this is the optimistic view — based on the assumption that drug companies can and will get moving on discovering new antibiotics to throw at the bacterial enemy. Since the ’90s pharmaceutical companies have not shown a great deal of enthusiasm for difficult antibiotic research. Unlike with heart medicines, people take antibiotics for a week rather than life, and because resistance means the drugs become useless after a while, there is just not much money in it.
Dr Livermore, whose grandmother died for lack of infection-killing drugs in 1945, is director of the antibiotic resistance monitoring laboratory of the Health Protection Agency (HPA). Last year, the HPA put out an alert about NDM1, urging health professionals to report all suspect cases.
Livermore is far from sanguine about the future.
“A lot of modern medicine would become impossible if we lost our ability to treat infections,” he says. He is talking about transplant surgery, for instance, where patients’ immune systems have to be suppressed to stop them rejecting a new organ, leaving them prey to infections, and the use of immunosuppressant cancer drugs.
The era of antibiotics is coming to a close.South Asia ‘superbug’ claims its first victim
BRUSSELS
Mr Denis Pierard, a microbiologist from AZ VUB hospital in Brussels where the victim had been treated since June, told Belgian media that the man was infected by the bacteria while being treated in a hospital in Pakistan.
“He was involved in a car accident in Pakistan. He was hospitalised with a leg injury and then repatriated to Belgium, but he was already infected,” the doctor said.
Despite receiving powerful antibiotics, the patient died.
According to a report on Belgian TV channel
The superbug — a bacterial gene called New Delhi metallo-lactamase-1 (NDM-1) — was first identified last year in a Swedish patient admitted to hospital in India.
Professor Peter Collignon, Canberra Hospital’s head of infectious diseases department, said the superbug has infected three Australians, including one patient who had plastic surgery in Mumbai.
These patients were just the “tip of the iceberg”, said Dr Collignon, adding: “There may well be more because it’s difficult to pick up this particular gene unless you’ve got sophisticated testing.”
British scientists sparked an angry response from India when they said “medical tourists” to the subcontinent were among 37 people who were found to be infected.
“We strongly refute the naming of the enzyme ... and also refute that hospitals in India are not safe for treatment including medical tourism,” the Indian Health Ministry said.
The gene, which is found in a number of different bacteria, produces an enzyme that renders even very strong antibiotics ineffective.
Dr Collignon blamed the new bugs on the “abuse” of antibiotics in medicine and also in agriculture, saying some countries used them on billions of chickens, which develop bacteria and are then consumed by humans.
The professor, who sits on World Health Organisation panels on antibiotics, called for a worldwide crackdown on antibiotic use along with a major hygiene campaign to stop the bugs spreading.
Singapore’s Health Ministry said there has not been any case reported locally to date: “Our hospitals have a robust surveillance and infection control system (eg stringent hand hygiene practices, etc) in place and we will continue to monitor the situation closely.
Cooperation from all is needed to stop germs from spreading. We can help by having good personal hygiene practices such as proper and frequent hand washing, and observing the strict visitation policy of hospitals to prevent cross infection.”
AFP, wi th addi tional rep orting by Esthe r Ng
BREATH TEST can identify different types of CANCER, say scientists
LONDON
Their preliminary results, printed in the
The sensor used gold nanoparticles to detect levels of so-called volatile organic compounds, measured in a few parts per billion, that became more elevated in cancer patients.
The device could provide an early warning system that flags the disease before tumours become visible in X-rays.
The study examined the breath of 177 volunteers, including healthy people and patients already diagnosed with different stages of the four types of cancer.
However, further tests with larger samples will be needed to determine the strength of the link between breath and cancer detection.
“These results are interesting and show that there is the potential to develop a single breath test to detect these cancers,” said Dr Lesley Walker of the CancerActive charity in the United Kingdom.
“Strengthening the methods for early diagnosis of cancer, as well as improved treatments will have a significant impact on cutting death rates,” she added.
— Scientists working on a breath test to detect cancer said in research published yesterday that they are now able to identify different types of the disease.British Journal of Cancer monthly, showed that the sensors could distinguish whether a patient had lung, breast, bowel or prostate cancer, irrespective of age, gender or lifestyle.AFP
Superbugs in UK
New bacteria from South Asia could spread worldwide, study warns
LONDON
Many hospital infections that were already difficult to treat have become even more impervious to drugs due to a recently-discovered gene that can jump across different species of bacteria.
Worryingly, the New Delhi metallo-beta-lactamase- 1 bacteria (NDM-1) are resistant even to carbapenems, a group of antibiotics often reserved as a last resort for treatment for multi-drug resistant bugs.
Researchers said the bugs had been brought into Britain by patients who travelled to India or Pakistan for cosmetic surgery.
In the new study, led by Cardiff University’s Timothy Walsh and Madras University’s Karthikeyan Kumarasamy, researchers set out to determine how common NDM-1 was in South Asia and Britain, where several cases had turned up.
They found 44 cases — 1.5 per cent of those screened — in Chennai, and 26 in Haryana, both in India. They also found the superbug in Bangladesh and Pakistan, as well as 37 cases in Britain.
NDM-1 was mostly found in E coli and K pneumoniae.
It was impervious to all antibiotics except two — tigecycline and colistin.
Crucially, the NDM-1 gene was found on DNA structures, called plasmids, that can be easily copied and transferred between bacteria, giving the bug “an alarming potential to spread and diversify”.
“Unprecedented air travel and migration allow bacterial plasmids and clones to be transported rapidly between countries and continents,” the authors said.
The emergence of these new strains could become a serious global health problem as the major threat shifts towards a broad class of bacteria, they warned.
Professor Walsh said “there are no new antibiotics that are going to be available in 10 years’ time”.
— “Health tourists” flocking to South Asia have carried a new class of antibiotic-resistant superbugs to Britain, researchers reported yesterday, warning that the bacteria could spread worldwide.AGENCIES

Another PILL that could cause a revolution
That seems possible, for these pills are beginning to revolutionise abortion around the world, especially in poor countries. One result may be tens of thousands of women’s lives saved each year.
Five-sixths of abortions take place in developing countries, where poor sterilisation and training often make the procedure dangerous. Up to 70,000 women die a year from complications from abortions, according to the World Health Organisation.
But researchers are finding an alternative that is safe, cheap and very difficult for governments to restrict — misoprostol, a medication originally intended to prevent stomach ulcers.
“I feel like people must have felt when they discovered the nuclear bomb,” says Dr Beverly Winikoff, president of Gynuity Health Projects, a non-profit research institution on reproductive health. “This technology is world-shaking.”
This pharmaceutical approach is called “medical abortion”.
In the United States and Europe it typically consists of two sets of “M” pills. The first is mifepristone, formerly known as RU486, and then a day or two later the misoprostol.
Using the drugs in combination produces a miscarriage more than 95 per cent of the time in early pregnancy. But mifepristone is difficult to obtain in much of the world, because it is used only to induce abortions.
In contrast, misoprostol is very widely available and cannot easily be banned because it is also used for ulcers and can save the lives of women with postpartum haemorrhages.
Whatever one thinks of misoprostol for abortions, it also is a potential lifesaver for women who haemorrhage after childbirth.
Could the decades-long global impasse over abortion worldwide be overcome — by little white pills costing less than US$1 ($1.35) each?operation_pesb ( Date: 04-Aug-2010 15:36) Posted:
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15:29:00 | 0.190 | 9,540,000 | Buy Up |
omg don't tell me it's reminser king again.
DESIGNER VIRGIN may NOT be a VIRGIN ? ? ? ?
MARRiES ONE WIFE GETS TWO VIRGINS

Sun, May 09, 2010
The New Paper
Woman discovers she has two vaginas | ||
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By SHREE ANN MATHAVAN IT was her first pap smear test and the Singaporean, in her mid-twenties, didn't expect any surprises. After all, she is young and healthy. But what was to have been a routine five-minute check-up last month turned complicated - she discovered she had two vaginas. The discovery was also a first for her doctor. Dr Chee Jing Jye, the medical director at The Obstetrics & Gynaecology Centre at Paragon Medical, had never encountered such a case in her 13 years of practice. The discovery was made after the young woman was physically examined and had a 3-D ultrasound scan for abnormalities in the womb. Fortunately, despite having two vaginas and two cervixes, her womb was fine. Still, the news came as a blow for the woman, said DrChee. The distraught woman declined to be interviewed by The New Paper. Dr Chee said that one of the first questions she asked was: "Am I normal?" The doctor, who is in her 30s, assured her that her condition isn't life-threatening and will not have a major impact on her life. She told The New Paper: "Theoretically, the chances of her getting pregnant in the future should not be much of a problem." |
Healthway Medical
19.5 cents | Buy
Shares gained 2.6 per cent to 19.5 cents, holding near 52-week high of 21 cents set last week.
DMG, has “Buy” call with 30 cents target, saying outlook favourable as healthcare group continues to make inroads in China using proceeds from placement of shares to World Bank’s International Finance Corp, other investors carried out earlier this year.
His interest in Healthway came under the spotlight after open market purchases via investment vehicle Kestrel Capital on 2 Jun bumped his deemed stake above 5%.
Latest purchases in the owner of Singapore’s largest network of private medical centers and clinics upped his deemed stake to 7.21% as at 10 Jun.
Never mind that Heathway’s net profits contracted 63.9% year on year for the first quarter of FY2010 --- its trading volumes surged tenfold overnight thanks to investor interest spurred by the smart money move.
128 million shares changed hands today, the highest since Jan this year.
The company generated net profits of S$1.36 million for 1Q2010.
Revenues for 1Q2010 were S$22.2 million, down 6.3% year-on-year. However, net margins fell due to an increase in operating costs, which include overheads, new doctors hires and start-up expenses in its new centres.
In the past 6 months, Healthway started several new centres offering family medicine and specialist services, namely ear, nose and throat surgery, eye surgery, general surgery, cardiology, sports medicine, psychiatry, paediatric pulmonology, paediatric endocrinology, paediatric neurology and child psychology.
The stock last closed at 20 cents, up 25% on steady trend compared to two weeks ago when Peter Lim's interest was made public.
The stock may already be at an estimated 22x PE for the current year (compared to 19x sector average), but DMG’s Lynette Tan has a ‘Buy’ call on the stock with target price at 30 cents.
Analysts like Healthway for its expansion plans.
It aims to double the total number of clinics in Singapore (including 60 specialist clinics) in the next 5 years to 200. Of this total, the number of primary healthcare clinics (including 20 dental practices) is expected to grow from 70 to 140.
It also plans to have a total of 8 medical centers in Shanghai, of which 6 are operational by this year.

Ernest Lim, CFA, CPA, a remisier with CIMB-GK Securities, said: "There has been much trading interest in Healthway post Mr Lim Eng Hock’s (better known as Peter Lim) announcement that he has become a substantial shareholder of Healthway in early June. In addition, the partial take over bid of Parkway spurs interest in healthcare stocks. However, investors should do their due diligence before jumping onto the bandwagon of healthcare stocks, as they have diverse fundamentals and trading at different valuations."
31 Dec 09 price S$ | Market cap S$ m | PE (x) | |||
2008 2009F 2010F | |||||
Parkway Holdings | 2.92 | 3301.2 | 94.8 | 34.9 | 36.3 |
Raffles Medical | 1.45 | 753.4 | 23.9 | 19.7 | 17.3 |
Thomson Medical Centre | 0.69 | 201.5 | 17.7 | 15.8 | 14.2 |
Health Management | 0.10 | 48.1 | -110.6 | N.A. | N.A. |
Pacific Healthcare | 0.11 | 30.9 | -2.6 | N.A. | N.A. |
Healthway Medical | 0.135 | 186.9 | 19.6 | 11.8 | 10.1 |
Average | 7.1 | 20.6 | 19.5 |
Healthway (5NG) 2010 JUNE 15 Tuesday
Day Hi 0.205 Last 0.200 vol 128,444,000
Day Lo 0.190 Chng 0.010
Tim. & SaleslTrad. SummarylQu.u. Tmack;0]
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0.200 500,000 Sold To Buyer
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0.200 395,000 Bought From Seller
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0.200 100,000 Bought From Seller
pharoah88 ( Date: 15-Jun-2010 17:56) Posted:
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PETER LIM is an INfamous BRAND for his
PiCKING of MULTi-BAGGERS
He PAiD S$2.50 for WiLMAR [HiGH S$7.29] 3 BAGGER
He PAiD S$0.15 for HEALTHWAY [TARGET S$0.45 ?] 3 BAGGER ?
RESEARCH ALERT-DMG reiterates 'Buy' on Healthway Medical |
SINGAPORE, June 7 (Reuters) - Following is a list of Singapore stock price target changes and rating changes on Monday.
COMPANY RIC BROKER RATING (PVS) TARGET PRICE (PVS) HEALTHWAY MEDICAL DMG (BUY) TARGET S$0.30
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pharoah88 ( Date: 08-Jun-2010 15:35) Posted:
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$ Healthway | Symbol: 5NG |
Currency: Singapore Dollar |
Last: | 0.2 | ![]() |
Vol (K): 128444.0 |
Trading | |||||
Updated Time | 15-Jun 17:05 | ||||
Open | 0.19 | High | 0.205 | Low | 0.19 |
Prev Close | 0.19 | Buy | - | Sell | - |
Volume(K) | 128444.0 | Buy Vol(K) | - | Sell Vol(K) | - |
52 Wk High | 0.19 | 52 Wk Low | 0.1 | 52 Wk Avg Vol | 8568.893 |
All Time High | 0.27 | All Time Low | 0.05 | ||
Comments | Near 52 wk high |
*Reporting Currency in SGD
Important: ShareJunction obtains our finance data from a third party. Check financial year before use. EPS values are recorded up to two decimal points.
Financials | |||
Date Updated | 31-May-2010 | Financial Year | 31-Dec-2009 |
Current Year Profit (After Tax) $'000,000 |
15.238 | Previous Year Profit (After Tax) $'000,000 |
9.555 |
Net Asset Per Share | -0.01 | Turnover $'000,000 | 225.01 |
Current Year EPS (After Interest and Tax) |
0.01 | Previous Year EPS (After Interest and Tax) |
0.01 |
PE Ratio (After Tax) | 15.0 | Times Covered | 4.6 |
Price (at update time) | 0.15 | Dividend Yield | 0.01 |
*Technical Analysis Information is updated Daily
Technicals | |||||
RSI | 76.82 | Williams %R | 0.0 | ||
Comments (RSI) | Overbought | Comments (W%R) | Overbought |
Intraday Chart

pharoah88 ( Date: 15-Jun-2010 14:50) Posted:
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